parkin
Parkin is a 465-amino-acid E3 ubiquitin ligase encoded by the PARK2 gene in humans. The PARK2 gene is on chromosome 6q25.2-q27. Parkin contains an N-terminal ubiquitin-like (Ubl) domain and a C-terminal arrangement of RING0, RING1, and RING2/IBR domains, which together support its ubiquitin‑ligase activity.
Parkin is central to mitochondrial quality control through mitophagy. When mitochondria are damaged, the serine/threonine kinase
Clinical significance. Mutations in PARK2 are among the most common genetic causes of early-onset Parkinson’s disease,
Other roles. Beyond neurodegeneration, Parkin participates in broader cellular processes including proteostasis, mitochondrial dynamics, and responses