6q252q27

6q25.2-q27 is a cytogenetic designation used in human genetics to denote a segment on the long arm of chromosome 6. It spans the region from band 6q25.2 to 6q27. In standard genome builds the region corresponds to a defined base-pair interval, with coordinates varying between assemblies such as GRCh37 and GRCh38. The notation is used in chromosomal karyotypes and in genome browsers to refer to this interval.

The interval lies on the distal part of the long arm of chromosome 6 and contains multiple genes as well as noncoding elements. Actual gene content depends on the reference genome; the region typically encompasses several protein-coding genes, microRNAs, and regulatory sequences. Variation within this interval can occur via deletions, duplications, or rearrangements that affect gene function or regulation.

In clinical cytogenetics, subregions of 6q may be involved in copy-number changes associated with developmental disorders, dysmorphisms, or congenital anomalies, and occasionally with cancer predispositions. Specific associations for 6q25.2-q27 are not universally established; reported phenotypes vary by exact breakpoint and patient, with outcomes depending on which genes are affected and how regulatory elements are disrupted.

Research on this region uses a combination of molecular cytogenetics, array-based comparative genomic hybridization, sequencing, and comparative genomics. Researchers map breakpoints, identify disrupted genes, and compare patient data with population databases. Public resources such as the UCSC Genome Browser, Ensembl, ClinVar, and DECIPHER are used to annotate and interpret findings.

See also: Chromosome 6, cytogenetic notation, copy-number variation.