Ser65

Ser65 refers to a specific site on the protein sequence of human T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). TIM-3 is an immune checkpoint protein that plays a crucial role in regulating T-cell responses, particularly in the context of cancer and autoimmune diseases. The amino acid at position 65 in the TIM-3 protein is serine (Ser).

Modifications at this serine residue, such as phosphorylation, have been investigated for their impact on TIM-3 function. Phosphorylation at Ser65 has been linked to changes in TIM-3's interaction with other proteins and its downstream signaling pathways. Research suggests that the phosphorylation status of Ser65 can influence T-cell exhaustion and the efficacy of anti-tumor immunity.

Studies have explored the role of kinases that can phosphorylate Ser65, as well as phosphatases that can dephosphorylate it. Understanding the regulation of Ser65 phosphorylation is of interest for developing novel immunotherapies aimed at modulating TIM-3 activity to enhance anti-cancer responses or suppress autoimmune inflammation. The precise functional consequences of Ser65 modification are still an active area of research.