p38JNK
p38JNK is not a single enzyme but a way to refer to two closely related branches of the mitogen-activated protein kinase (MAPK) signaling system: the p38 MAP kinases and the c-Jun N-terminal kinases (JNKs). These families respond to cellular stress and inflammatory signals and regulate diverse cellular outcomes, including gene expression, differentiation, proliferation, and apoptosis. There is no official kinase named “p38JNK”; the term is sometimes used informally to discuss the two MAPK subfamilies together.
p38 MAP kinases comprise four isoforms: p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). They are
JNKs include JNK1, JNK2, and JNK3 (MAPK8, MAPK9, MAPK10). They are activated predominantly by MKK4 and MKK7
Both p38 and JNK pathways are subject to cross-talk with other signaling networks and are common targets