osteoinductive
Osteoinductive refers to the property of a material or biological signal to induce undifferentiated cells, such as mesenchymal stem cells, to proliferate and differentiate into osteoblasts, initiating new bone formation. In this context, osteoinduction involves recruiting host cells to a defect and providing signals that drive their osteogenic differentiation. This distinguishes it from osteoconduction, which describes a scaffold that supports bone growth, and from osteogenesis, which involves the direct contribution of viable osteogenic cells.
Osteoinduction typically relies on signaling molecules that stimulate bone formation. Key factors include bone morphogenetic proteins
Clinically, osteoinductive materials include demineralized bone matrix, certain allografts, and biomaterials loaded with growth factors like
Limitations and considerations include variability in osteoinductive activity due to processing methods and patient factors, potential