ossealization
Ossealization, also spelled ossealization, refers to the biological process by which bone tissue forms and becomes a stable part of the skeletal system. In common usage, it is closely aligned with ossification, the broader term for bone formation that occurs during development, growth, and ongoing remodeling.
There are two primary pathways of ossealization. Intramembranous ossification occurs when mesenchymal cells directly differentiate into
Cellularly, ossealization involves osteoprogenitor cells that become osteoblasts, synthesis of osteoid, and subsequent mineral deposition of
Clinically, ossealization is central to fracture healing, congenital skeletal development, and disorders characterized by abnormal bone