oncolytische
Oncolytische (Dutch for "oncolytic") describes agents or processes that selectively destroy cancer cells, most commonly referring to oncolytic viruses used in cancer therapy. Oncolytic viruses are engineered or naturally occurring viruses that preferentially infect, replicate within, and lyse tumor cells while sparing normal tissue. Tumor selectivity can arise from inherent viral tropism, exploitation of defects in cancer cell antiviral responses, or genetic modification of the virus.
Mechanisms of action include direct oncolysis, release of tumor antigens after cell lysis, and induction of
Clinical development has produced approved products in certain jurisdictions, for example talimogene laherparepvec (T-VEC) for melanoma
Research continues into optimizing viral design, improving systemic delivery, and integrating oncolytic strategies into broader immuno-oncology