ogacceptor

ogacceptor is not a widely recognized term in major biological databases. In some discourses, especially within the study of O-GlcNAcylation, the phrase is used informally to denote a protein or molecular site that serves as the substrate for the enzyme O-GlcNAc transferase (OGT). In that usage, an "OG acceptor" or "O-GlcNAc acceptor" is any protein or peptide bearing a serine or threonine residue modified by the addition of N-acetylglucosamine (GlcNAc). The modification is dynamic, reversible, and occurs primarily in the nucleus and cytosol. The set of OG acceptors is diverse, including transcription factors, splicing factors, cytoskeletal and nuclear pore complex components; the exact substrates can vary by cell type and condition. Enzymes OGT and O-GlcNAcase (OGA) regulate the cycling of O-GlcNAc on these acceptors, affecting many cellular processes such as transcription, signaling, and stress responses. Representative validated O-GlcNAc acceptors reported in the literature include tau protein, p53, Sp1, CREB, and the RNA polymerase II C-terminal domain, among others.

In other contexts, ogacceptor may appear as a variable name or identifier in software, databases, or data sets, where its meaning depends on the specific project documentation. If you encounter the term in a particular resource, consult the associated glossary or methods section for precise usage.