nukleotiddrivere
Nukleotiddrivere, often translated as nucleotide drivers, is a term used in molecular biology to describe cellular components and processes that govern the availability and turnover of nucleotides, the building blocks of DNA and RNA. The phrase is not universally standardized and may be used informally in reviews or discussions to emphasize rate-limiting or controlling steps in nucleotide metabolism.
The concept encompasses multiple layers of control, including de novo biosynthesis, salvage pathways, nucleotide transport, degradation,
Mechanisms underlying nukleotiddrivere include rate-limiting enzymes (for example, ribonucleotide reductase and thymidylate synthase), feedback regulation by
Clinical and research relevance arises because rapidly proliferating cells, such as cancer cells, often exhibit elevated
See also: Nucleotide metabolism, Ribonucleotide reductase, Thymidylate synthase.