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norspermidine

Norspermidine is a biogenic polyamine closely related to spermidine, differing by a single methylene group in its carbon chain. Like other polyamines, norspermidine is a small aliphatic molecule bearing multiple amino groups and a flexible backbone, enabling interaction with nucleic acids and other negatively charged biomolecules. In nature it has been detected in various bacteria and some photosynthetic organisms, where it is thought to contribute to growth, stress response, and cellular architecture.

Biosynthesis of norspermidine parallels that of spermidine in many organisms, using a decarboxylated S-adenosylmethionine-derived aminopropyl donor

In biological systems, polyamines including norspermidine participate in stabilization of DNA and RNA structures, regulation of

to
attach
a
propylamine
moiety
to
putrescine.
In
certain
bacteria,
specialized
enzymes
such
as
norspermidine
synthase
have
been
described
that
generate
norspermidine
instead
of
spermidine,
yielding
the
norspermidine
homologue.
gene
expression,
and
modulation
of
ion
channels.
Norspermidine
has
been
studied
for
its
effects
on
biofilm
formation
and
microbial
physiology,
and
as
a
tool
to
probe
polyamine
function.
Research
into
norspermidine
is
ongoing,
with
interest
in
understanding
its
role
in
microbial
ecology
and
its
potential
as
a
target
for
antimicrobial
strategies.
There
are
no
approved
medical
uses
for
norspermidine,
and
it
is
mainly
encountered
in
laboratory
and
environmental
contexts
as
part
of
polyamine
research.