nitrogensubstituted
Nitrogen-substituted, or nitrogen-substituted, refers to compounds in which a hydrogen atom attached to a nitrogen atom is replaced by one or more substituents. This broad concept encompasses many familiar classes in organic chemistry, including amines, amides, and heterocycles, as well as more complex nitrogen-containing frameworks. In practice, substitution at nitrogen changes both the chemical and physical properties of a molecule, such as basicity, polarity, steric profile, and metabolic stability.
Common instances include N-substituted amines, where primary amines become secondary or tertiary amines when alkyl or
The effects of nitrogen substitution are context dependent. Substitution at nitrogen generally reduces the basicity of
Nomenclature often denotes the substituent with prefixes such as N-, for example N-methyl, N-phenyl, or N,N-dialkyl,