nickelcorrinoid
Nickelcorrinoid is a class of organometallic compounds that feature a central nickel atom coordinated within a corrin ring. The corrin ring is a macrocyclic ligand similar to the porphyrin ring found in heme and chlorophyll, but it is characterized by a direct bond between two adjacent beta-carbons, leading to a reduced ring system. Nickelcorrinoids are primarily found in biological systems, where they play crucial roles in various enzymatic reactions.
The most well-known nickelcorrinoid is the active cofactor in the enzyme methyl-coenzyme M reductase (MCR), which
Beyond methanogenesis, nickelcorrinoids have been identified in other bacterial and archaeal enzymes. These enzymes are often