nesprinproteiner
Nesprin proteins, also known as nuclear envelope spectrin-repeat proteins, are a family of large cytoskeletal proteins located in the nuclear envelope. They play a crucial role in connecting the nucleus to the cytoskeleton, primarily to the actin filaments. This connection is essential for maintaining nuclear shape and position within the cell, as well as for transmitting mechanical forces from the cell exterior to the nucleus.
The nesprin protein family consists of several isoforms, with Nesprin-1 and Nesprin-2 being the most well-studied.
Through their interaction with the LINC complex, nesprins establish a physical bridge between the outer nuclear