nanopartikkelsporinganalyse

Nanopartikkelsporinganalyse, also known as nanoparticle tracking analysis (NTA), is a technique used to measure the size distribution of nanoparticles in a liquid suspension. It is widely used in research and industry for quality control, characterization, and monitoring of nanoparticle-based products. The technique is based on the principle of light scattering, where nanoparticles passing through a laser beam cause a temporary increase in light intensity, which is detected by a camera. The size of the nanoparticles can be determined from the duration of this light scattering event.

NTA offers several advantages over other nanoparticle sizing techniques. It is a label-free method, meaning it does not require any modification of the nanoparticles. It also provides real-time, single-particle measurements, allowing for the analysis of polydisperse samples. The technique is relatively fast and can analyze a large number of particles in a short period, making it suitable for high-throughput applications.

However, NTA also has some limitations. It is primarily suitable for nanoparticles in the size range of 10 nm to 1 µm. Smaller particles may not scatter enough light to be detected, while larger particles may cause multiple scattering events, leading to overestimation of their size. Additionally, the technique is sensitive to the refractive index of the particles and the surrounding medium, which can affect the accuracy of the size measurements.

In conclusion, nanopartikkelsporinganalyse is a powerful tool for the characterization of nanoparticles. Its advantages include being label-free, providing real-time measurements, and being suitable for high-throughput applications. However, its limitations include the size range it can analyze and its sensitivity to the refractive index of the particles and the surrounding medium. Despite these limitations, NTA is widely used in various fields, including nanomedicine, environmental science, and materials science.