myelodysplastiset
Myelodysplastiset is a Finnish term referring to myelodysplastic syndromes or to cells showing dysplasia in the bone marrow. Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and morphologic dysplasia in one or more myeloid lineages; patients typically present with cytopenias, especially anemia, fatigue, infections, or bleeding tendencies.
The underlying biology often involves somatic mutations in genes that regulate RNA splicing, epigenetic modification, and
Diagnosis involves persistent cytopenias; examination of blood smear with dysplastic neutrophils, hypolobulated megakaryocytes; bone marrow biopsy
Management ranges from observation for low-risk disease to disease-modifying therapy in higher risk groups. Supportive care