mixedtrial
Mixedtrial is a term used in research methodology to describe a study design that combines multiple trial methodologies within a single project. In a mixed trial, elements of randomized controlled trials (RCTs) may be integrated with observational or real-world components, or multiple data-generating strategies are used. The aim is to balance internal validity with external validity and to improve efficiency by leveraging information from different sources.
Design and methods. A mixed trial may include an RCT arm alongside a registry-based or cohort arm;
Applications and examples. Mixed trials are used in clinical research to evaluate efficacy under controlled conditions
Advantages and challenges. Benefits include enhanced external validity, more efficient use of data, and faster decision-making.
See also: mixed-methods research, pragmatic trials, adaptive trial designs, hybrid designs.