mixedgenotype
Mixedgenotype, frequently rendered as mixed genotype or mixed-genotype in literature, refers to a situation in which an organism or a sample contains two or more genetically distinct cell lines or organisms. It is distinct from a uniform genotype across all cells. Mixed genotypes most commonly arise from mosaicism, where a post-zygotic mutation creates a lineage of cells with a different genotype within the same individual. Chimerism, the presence of two genetically distinct cell populations derived from different zygotes, can also produce a mixed genotype, such as in natural twin chimeras or after bone marrow or organ transplantation.
In infectious disease contexts, a host may harbor multiple genotypes of a pathogen, such as viruses or
Detection and interpretation rely on genetic testing with sufficient resolution. Standard genotyping may show ambiguous signals
Implications vary by context. Mosaicism or chimerism may produce mosaic phenotypes and affect transplantation, pregnancy, and