metformins
Metformin is a biguanide oral antihyperglycemic used as the first-line pharmacologic therapy for many adults with type 2 diabetes. It is also prescribed for polycystic ovary syndrome (PCOS) and, in certain guidelines, for prediabetes or gestational diabetes. It is available in immediate-release and extended-release forms.
Mechanism: Metformin lowers hepatic glucose production, improves insulin sensitivity, and reduces intestinal glucose absorption. It does
Administration and dosing: Treatment typically begins at a low dose with meals to minimize gastrointestinal side
Pharmacokinetics and safety: Metformin is excreted unchanged by the kidneys and is not metabolized by the liver.
History and brand names: Metformin was developed in the mid-20th century and introduced for medical use in