mesotherapy

Mesotherapy is a medical technique that involves the injection of small amounts of drugs, vitamins, minerals, or enzymes into the mesoderm, the layer of tissue just beneath the skin, with the aim of treating local issues or providing cosmetic benefits. It was developed by French physician Michel Pistor in the 1950s and has since been used in various forms around the world.

The injections are microinjections delivered into the dermis or subcutaneous tissue, often using fine needles, cannulas, or specialized devices. Treatment patterns are individualized and may target specific areas such as the face, neck, abdomen, arms, or thighs. A wide range of substances has been used in mesotherapy, including vitamins, amino acids, minerals, enzymes, plant extracts, hyaluronic acid, and phosphatidylcholine or other lipolytic agents. The intended effects range from improved skin texture and hydration to reduction of localized fat and cellulite, and, in some cases, support for hair growth.

Indications cited in practice include localized fat deposits, cellulite, skin rejuvenation, scar treatment, and alopecia. Evidence regarding efficacy is mixed and often limited by small, methodologically weak studies. Some trials report modest improvements, but high-quality, large-scale research is lacking. Safety concerns include pain, swelling, bruising, infection, allergic reactions, and rare complications such as nodules, scarring, or tissue damage. Regulatory status and standards of care vary by country; practitioner training and strict aseptic technique are important considerations.