mechanoreceptorsMerkel
Merkel cell–neuron complexes are a type of mechanoreceptor in the skin. They consist of a Merkel cell, a specialized epidermal cell, in close contact with a small-diameter afferent nerve ending of a myelinated Aβ fiber. In humans they are most concentrated in areas of high tactile acuity, such as the fingertips and lips, and are present in both glabrous and hairy skin, though regional density varies.
Function and response properties: Merkel complexes detect fine details of shape, texture, and edges through sustained
Transduction and signaling: Mechanical stimulation opens mechanosensitive channels, notably Piezo2, in Merkel cells. Merkel cells are
Structure and development: The receptor is a coordinated two-part complex (Merkel cell and associated nerve ending)
Clinical relevance: Merkel cell dysfunction can reduce tactile discrimination. Merkel cell carcinoma is a rare, aggressive