mecCcarrying
MecC-carrying refers to Staphylococcus aureus and related staphylococci that harbor the mecC gene, a mecA homolog, within the SCCmec genetic element. The mecC gene encodes an altered penicillin-binding protein, PBP2c, which reduces affinity for beta-lactam antibiotics and confers methicillin resistance.
MecC is located on a distinct SCCmec element, designated SCCmec XI, and is commonly associated with livestock-adapted
Standard phenotypic tests and many mecA-targeted diagnostics may fail to detect mecC-mediated resistance, leading to underdiagnosis.
Clinically, mecC-carrying MRSA is resistant to beta-lactams but often remains susceptible to non-beta-lactam antibiotics; treatment should
Global reports show mecC-carrying MRSA is present in several regions but remains less common than mecA MRSA.