leukoprotection
Leukoprotection is the set of medical strategies aimed at preserving or protecting leukocytes, particularly neutrophils, during exposure to cytotoxic therapies or other insults that threaten white blood cell counts. The goal is to reduce the risk of infection, allow cancer treatments to proceed as planned, and shorten interruptions in therapy.
The mainstay of leukoprotection is pharmacologic augmentation of leukopoiesis. Granulocyte colony-stimulating factors (G-CSFs) such as filgrastim
Indications include many cytotoxic regimens for solid tumors and hematologic malignancies, autologous stem cell transplantation, and
Guidelines generally recommend G-CSF prophylaxis for regimens with a high risk of febrile neutropenia and consider