lamellipodin
Lamellipodin is an actin-regulatory adaptor protein encoded by the RAPH1 gene in humans. It localizes to lamellipodia at the leading edge of migrating cells and contributes to the control of actin filament polymerization and cell motility.
Lamellipodin contains multiple proline-rich regions that recruit Ena/VASP family proteins via their EVH1 domains, promoting actin
By coordinating Ena/VASP-mediated elongation with Rac1- and PI3K-driven signaling, lamellipodin supports lamellipodium formation and sustained protrusions,
Lamellipodin is conserved in vertebrates and is studied for its role in cell motility across various cell