ihoreaktionen

Ihoreaktionen refers to the Jarisch-Herxheimer reaction, a temporary worsening of symptoms that can occur after initiating antibiotic treatment for certain bacterial infections. This reaction is most commonly observed in the treatment of syphilis, but can also happen with other spirochetal infections like Lyme disease and leptospirosis. The exact mechanism is not fully understood but is thought to be an inflammatory response to the sudden release of endotoxins from large numbers of killed bacteria.

Symptoms typically begin within a few hours of the first antibiotic dose and can include fever, chills, headache, muscle aches, rash, and a drop in blood pressure. These symptoms are generally mild and self-limiting, resolving within 24 hours. More severe reactions are rare.

The reaction is not a sign of antibiotic allergy or treatment failure. It indicates that the antibiotic is effective in killing the bacteria. Management usually involves symptomatic treatment with fever reducers and fluids. In cases of severe reactions, particularly in pregnant women with syphilis, antibiotic treatment may be temporarily paused or adjusted. The Jarisch-Herxheimer reaction highlights the importance of patient education regarding potential side effects when starting treatment for these specific infections.