histamin2blockerare
Histamin2blockerare, commonly known as H2 receptor antagonists (H2 blockers), are a class of medicines that reduce gastric acid production by blocking histamine H2 receptors on gastric parietal cells. They are used to treat peptic ulcers, gastroesophageal reflux disease (GERD), dyspepsia, and to prevent NSAID-induced ulcers, among other acid-related disorders.
Mechanism of action: H2 blockers competitively inhibit histamine at the H2 receptors, leading to a reduction
Common agents: Examples include famotidine, nizatidine, cimetidine, and ranitidine. Ranitidine has been withdrawn from many markets
Indications and use: They are typically used for short-term relief of heartburn and dyspepsia, treatment and
Safety and adverse effects: H2 blockers are generally well tolerated. Common side effects include headache, dizziness,
Drug interactions: Cimetidine notably inhibits several cytochrome P450 enzymes, increasing the potential for interactions with other
History and status: Introduced in the 1970s as a major advance in acid suppression. Over time, newer