hematoxilineozin
Hematoxilineozin is a synthetic heterocyclic substance that was first reported in a 2022 peer‑reviewed chemistry journal. The molecule combines a benzodioxazole core with a substituted phenyl ring, giving it a planar aromatic structure and moderate lipophilicity. It is not found in nature and has only been produced in laboratory settings.
The compound can be prepared by a one‑step Friedel–Crafts alkylation of hematoxylin with an oxazoline reagent,
In vitro studies have shown that hematoxilineozin exhibits modest inhibitory activity against the protein kinase CK2,
Potential applications of hematoxilineozin include use as a chemical probe for kinase research and as a scaffold
The literature on hematoxilineozin is limited to the initial synthesis report and a handful of computational