glialheterogenitet
Glial heterogeniteit, or glial heterogeneity, describes the variation observed among glial cells—such as astrocytes, oligodendrocytes, microglia, and Schwann cells—in morphology, gene expression, signaling roles, and physiological properties across brain regions, developmental stages, and environmental contexts.
Because glia are not a uniform class, astrocytes show regionally distinct transcriptional profiles and calcium signaling
Heterogeneity arises from developmental lineage, local cues from neurons and vasculature, and intrinsic genetic programs, as
Functional implications of glial diversity include influences on synapse formation and pruning, modulation of neuronal metabolism
Methods used to study glial heterogeniteit include single-cell RNA sequencing, spatial transcriptomics, lineage tracing, and in
Clinical and research relevance is substantial. In disease and injury, glial heterogeneity shapes pathology and therapeutic