gB2h

gB2h is a label used in some bioinformatics and teaching datasets to denote a hypothetical gene and its predicted protein product. It is not part of any standardized public nomenclature, and there is no single organism universally associated with the name. Because it is context-dependent, gB2h entries vary between projects and publications.

In common classroom or demonstration usage, gB2h is described as encoding a small to medium-sized cytosolic protein, roughly 20–40 kDa, that may contain a glycine-binding motif and a two-helix structural element. These features are hypothetical; they illustrate how researchers interpret sequence data, motifs, and domain predictions. Functional assignments for gB2h are speculative until experimental evidence is obtained.

Nomenclature and interpretation: The construction of the "gB2h" label typically combines shorthand indicators (for example, a glycine-binding motif abbreviated as gB) with a variant or motif descriptor (such as 2h for two helices or a second variant). Because gB2h is not standardized, the exact meaning can differ by dataset, and readers should treat it as a provisional annotation rather than a confirmed function.

Role in education and research practice: gB2h is often used to illustrate the workflow of genome annotation, from sequence similarity searches to motif prediction, domain assignment, and the generation of hypotheses about protein function. It also serves as a cautionary example of how hypothetical proteins require experimental validation to move beyond conjecture.

See also: hypothetical protein, gene annotation, protein domain, sequence similarity search, functional characterization.