forcefromlipid
forcefromlipid (often written Forcefromlipid) is a biophysics concept describing the mechanical forces a lipid bilayer exerts on embedded biomolecules and membrane proteins. It arises from several factors inherent to the bilayer, including hydrophobic mismatch, the lateral pressure profile, and membrane curvature and composition. Together, these factors generate forces that can influence conformation, orientation, and activity of membrane components without external inputs.
Hydrophobic mismatch between a protein’s transmembrane region and the surrounding bilayer thickness can induce tilt, bending,
In practice, forcefromlipid helps explain mechanosensitive channel gating, protein stability in different lipid environments, and peptide
Measurement and modeling rely on molecular dynamics simulations to compute forces on proteins from surrounding lipids,
See also: lipid bilayer, membrane tension, hydrophobic mismatch, mechanotransduction, Helfrich energy.