fluoroquinolonessince
Fluoroquinolonessince is a term used to describe the era in medical practice and policy that began with the development and widespread clinical use of fluoroquinolone antibiotics. While not a standard term in major pharmacology glossaries, it serves as a concise label for examining the scientific, clinical, and regulatory changes associated with this drug class.
Fluoroquinolones are synthetic antimicrobials that inhibit bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA
Prolonged and broader use brought significant safety concerns. Adverse effects include tendinopathy and tendon rupture, central
Resistance has emerged through mutations in DNA gyrase and topoisomerase IV, as well as plasmid-mediated mechanisms.
In current practice, fluoroquinolones remain valuable for specific indications but are commonly reserved for cases where