fibrinnett

Fibrinnett is a biomaterial composed of an interconnected network of fibrin fibers that forms a porous scaffold. It is produced by polymerization of fibrinogen into fibrin in the presence of thrombin and calcium, creating a three-dimensional mesh whose pore size and fibrin density can be tuned. The term is used in biomedical literature to describe laboratory or engineered fibrin-based networks that resemble natural clots and early extracellular matrices.

Structure and tunability: The network comprises polymerized fibrin fibers that create interconnected pores. The mechanical properties and degradation rate are controlled by thrombin concentration, calcium level, factor XIII crosslinking, and the addition of reinforcing polymers or nanoparticles. Fibrinnett can be formed as hydrogels or solid scaffolds and can be loaded with cells, growth factors, or drugs.

Applications: Used in tissue engineering as a provisional matrix, in wound healing studies, vascular biology as a clot model, drug delivery, and as a model for fibrinolysis. It can serve as a basement for endothelial or mesenchymal cell growth. In research, fibrinnett supports 3D cell culture and enables controlled release of bioactive molecules.

Limitations and regulation: Because fibrin is a biological material sourced from plasma, there is batch variability and potential immunogenicity. Sterilization and storage conditions influence stability. Not generally approved as a standalone medical device; applications are largely experimental or combinational. Ongoing research aims to standardize production and improve mechanical strength and reproducibility.