fastløsningsfordelingskoeffisient
Fastløsningsfordelingskoeffisient, often abbreviated as log P or log Kow, is a dimensionless quantity used in chemistry and pharmacology to describe the lipophilicity of a compound. It is defined as the logarithm of the ratio of the concentration of a solute in a lipid phase (typically octanol) to its concentration in an aqueous phase (typically water) at equilibrium. This ratio, often referred to as the partition coefficient (P), is then expressed on a logarithmic scale to accommodate a wide range of values and to make the distribution of lipophilic and hydrophilic compounds more manageable.
A high log P value indicates that a compound is more soluble in lipids than in water,
The determination of log P can be achieved through experimental methods, such as the shake-flask method, or