fascinatelike
Fascin-like refers to a group of actin-binding proteins that resemble fascin in sequence and function. Fascin is a small family of proteins that cross-link filamentous actin (F-actin) into tight, parallel bundles, enabling the formation of cellular protrusions such as filopodia. Fascin-like proteins share conserved actin-binding domains and often promote similar bundling activity, though their regulatory control and tissue distribution can vary across species and paralogs.
In vertebrates, multiple FSCN genes encode fascin-like proteins, most notably FSCN1, FSCN2, and FSCN3, which show
Biological and medical significance: Changes in fascin-like protein levels influence cell morphology and motility. Overexpression of
Related topics include the actin cytoskeleton, filopodia, invadopodia, and the protein fascin.