eplérénone

Eplerenone is a medication classified as a selective aldosterone receptor antagonist. It is primarily used to treat certain cardiovascular conditions. Specifically, it is prescribed to reduce the risk of cardiovascular events, such as death and hospitalization for heart failure, in patients who have had a recent heart attack (myocardial infarction). It is also used in combination with other medications to manage high blood pressure (hypertension).

The mechanism of action for eplerenone involves blocking the effects of aldosterone, a hormone produced by the adrenal glands. Aldosterone plays a role in regulating blood pressure and fluid balance by promoting sodium and water retention and potassium excretion. In conditions like heart failure and after a heart attack, excessive aldosterone can contribute to fluid overload, electrolyte imbalances, and adverse changes in the heart and blood vessels. By antagonizing aldosterone receptors, eplerenone reduces these harmful effects, leading to a decrease in blood pressure and improved cardiac function.

Eplerenone is taken orally, usually once or twice a day, depending on the prescribed dosage. Common side effects can include elevated potassium levels (hyperkalemia), dizziness, and fatigue. Due to the risk of hyperkalemia, regular monitoring of potassium levels in the blood is often recommended, especially in patients with kidney problems or those taking other medications that can increase potassium. It is important to consult with a healthcare professional for proper diagnosis, treatment, and management when considering eplerenone.