eosinófilomialgia

Eosinophilia-myalgia syndrome is a rare, potentially serious medical condition characterized by severe muscle pain (myalgia) and a significant increase in eosinophils, a type of white blood cell, in the blood. The condition was first recognized in the late 1980s, with a notable outbreak linked to contaminated L-tryptophan dietary supplements. The exact cause of eosinophilia-myalgia syndrome is not fully understood, but it is believed to be an autoimmune response triggered by an environmental factor, most commonly the contaminated L-tryptophan.

Symptoms can vary in severity and onset, typically appearing weeks after exposure to the suspected trigger. In addition to muscle pain, individuals may experience skin rashes, joint pain, fatigue, shortness of breath, and neurological symptoms such as numbness or tingling. In severe cases, the syndrome can lead to progressive fibrosis of internal organs, including the lungs and heart, which can be life-threatening. Diagnosis involves a combination of clinical symptoms, elevated eosinophil counts, and sometimes skin biopsies. Treatment focuses on managing symptoms and reducing inflammation, often involving corticosteroids. Prompt identification and discontinuation of the offending agent are crucial for recovery.