eIF4ARNA

eIF4ARNA is a term that appears in some scientific discussions to describe RNA molecules or RNA elements that interact with the eukaryotic initiation factor 4A (eIF4A). It is not a formally defined gene or universally recognized class of RNAs, but rather a descriptive label used to discuss RNA substrates, motifs, or aptamers that engage with eIF4A during translation initiation or its regulation.

Context on eIF4A: eIF4A is a DEAD-box RNA helicase that operates within the eIF4F complex, along with eIF4E and eIF4G. Its primary function is to unwind secondary structures in the 5’ untranslated region of mRNAs to facilitate ribosome scanning and cap-dependent translation. In humans, multiple isoforms exist, notably eIF4A1 and eIF4A2; a distinct protein called eIF4A3 is part of the exon junction complex and has different roles.

Role and examples of eIF4ARNA: In discussions of eIF4ARNA, researchers may refer to RNA sequences or structural motifs that recruit eIF4A to an RNA substrate or modulate its helicase activity. RNA aptamers created to bind eIF4A represent a well-studied example, used to inhibit or probe the helicase’s function in vitro. Viral RNAs and cellular mRNAs with particular secondary structures can also be described as interacting with eIF4A, highlighting the enzyme’s involvement in diverse translational contexts.

Significance: Studying eIF4ARNA helps clarify how RNA structure and RNA–protein interactions govern translation initiation and how these processes respond to cellular conditions. This area has implications for understanding viral translation, stress responses, and approaches to target eIF4A in therapeutic strategies.

See also: eIF4A; eIF4F; 4E-BPs; mTOR; RNA helicase; RNA aptamer.