cynarin

Cynarin is a natural phenolic compound found in artichokes (Cynara cardunculus). It is one of several polyphenols identified in artichoke leaf extracts and is often listed as a marker constituent in standardized preparations. The name cynarin derives from the plant genus Cynara.

In artichokes, cynarin is associated with the characteristic flavor profile and is thought to contribute to digestive-related properties attributed to artichoke extracts. Some traditional and contemporary uses of artichoke leaf preparations emphasize a choleretic effect, meaning they may promote bile production, which can aid digestion. Research on cynarin specifically is limited, and much of the claimed activity is considered to reflect the effects of artichoke extracts as a whole rather than cynarin alone.

Use and research: Cynarin-containing artichoke leaf preparations are marketed as dietary supplements for digestive support, dyspepsia, and liver health. The clinical evidence for the specific role of cynarin is limited, and effects are generally attributed to the extract’s combined polyphenolic content. More rigorous studies are needed to clarify cynarin’s individual contributions.

Safety and regulation: Artichoke-based products are typically well tolerated, but some individuals may experience gas, heartburn, or allergic reactions. People with gallbladder disease, bile duct obstruction, or those taking medications that affect bile flow should consult a healthcare provider before using bile-stimulating preparations. As with any supplement, discuss potential interactions with medications or existing health conditions with a clinician.