cyclohexane12dicarboxylate

Cyclohexane-d12 refers to the perdeuterated isotopologue of cyclohexane, in which all twelve hydrogen atoms are replaced by deuterium. This isotope substitution leaves the compound chemically similar to cyclohexane but alters its nuclear magnetic resonance and vibrational properties. The designation cyclohexane-d12 is the standard, while the string cyclohexane12d appears to be a typographical variant rather than a separate compound.

The primary use of cyclohexane-d12 is as a solvent in nuclear magnetic resonance (NMR) spectroscopy and other analytical techniques. Because deuterium does not produce signals in proton NMR, cyclohexane-d12 provides a nonprotonated, nonpolar medium that minimizes background interference. It is commonly employed for dissolving organic solutes in experiments where a low-background, inert solvent is advantageous. Depending on the level of isotope exchange, trace amounts of non-deuterated hydrogen may still yield small residual signals, which researchers account for in spectral interpretation.

Preparation of cyclohexane-d12 generally involves catalytic exchange of cyclohexane with deuterium sources or synthesis from deuterated reagents. Physically, its properties are closely aligned with those of ordinary cyclohexane: a nonpolar, volatile hydrocarbon that is flammable and handled under standard laboratory safety practices. The boiling point and density are similar to those of cyclohexane, with small shifts due to isotope effects.

Safety and handling follow typical hydrocarbon guidelines: flammable liquid; use in well-ventilated areas away from ignition sources; store in appropriate containers and observe standard precautions for chemical solvents.