cisaconitylbased
Cisaconitylbased refers to chemical systems, materials, or pharmaceutical conjugates that incorporate the cis-aconityl moiety as a pH-sensitive linker or building block. The term is most commonly used in prodrug design and polymer-drug conjugates, where a drug molecule or active ligand is chemically linked through a cis-aconityl group derived from cis-aconitic anhydride. Such linkages are designed to be relatively stable at physiological pH but cleavable in acidic environments, enabling targeted or triggered release of the active agent.
Chemistry and mechanism: In cisaconityl-based constructs, the active molecule, typically bearing a reactive amine or hydroxyl
Applications: Cisconitylbased designs are widely explored in prodrugs and polymer-drug conjugates to improve solubility, pharmacokinetics, and
Synthesis and considerations: Typical synthesis involves reacting an API with cis-aconitic anhydride or a related activated
See also: prodrug, pH-sensitive linkers, cis-aconitic anhydride, drug delivery systems.