cdtA

CdtA is a gene that encodes a component of the cell division and elongation machinery in bacteria, particularly in species such as Escherichia coli and related bacteria. It is often associated with the cell division process, playing a role in the regulation of cytokinesis and cell wall synthesis. The CdtA protein is believed to be involved in the coordination of cell wall remodeling during cell division, ensuring proper separation of daughter cells.

The function of CdtA is closely linked to bacterial cell cycle regulation. It interacts with other proteins involved in septum formation and cell wall integrity, contributing to the spatial and temporal control of division site placement. Disruption of cdtA can result in abnormal cell division, leading to filamentous or irregularly shaped bacteria, indicating its importance for normal cellular morphology.

CdtA has been studied primarily through genetic and microbiological approaches. Analysis of mutants lacking cdtA reveals defects in cell separation and division fidelity. Its conservation across various bacterial species suggests an essential role in maintaining cell cycle efficiency and structural stability.

While detailed structural information about CdtA is limited, it is often classified within the broader group of cell division proteins that share interaction domains for recruitment to the division site. Its regulation is influenced by environmental conditions and cellular stress responses, underscoring its role in adapting bacterial growth to changing environments.

Due to its conserved nature and critical function in bacterial division, CdtA is considered a potential target for antibacterial strategies aimed at disrupting bacterial proliferation. However, further research is necessary to fully elucidate its mechanisms and interactions within the cell division complex.