cFLIP
cFLIP, or cellular FLICE-like inhibitory protein, is a regulator of death receptor–mediated programmed cell death in humans. It is encoded by the CFLAR gene and functions primarily at the death-inducing signaling complex (DISC) to inhibit the activation of caspase-8, thereby blocking apoptosis in response to death receptors such as Fas and TRAIL receptors. cFLIP also participates in modulating other signaling pathways, including inflammatory and survival signals, depending on cellular context.
Protein structure and isoforms: cFLIP proteins contain two N-terminal death effector domains (DEDs) that enable binding
Function and mechanisms: At the DISC, cFLIP variants compete with procaspase-8 for FADD binding, inhibiting caspase-8
Regulation and clinical relevance: CFLAR expression is controlled by transcriptional and post-translational mechanisms, including NF-κB signaling