butenafiini

Butenafine is a synthetic benzylamine antifungal medication. It is primarily used topically to treat superficial fungal infections of the skin. Butenafine is effective against a range of dermatophytes, yeasts, and some molds. Its mechanism of action involves inhibiting squalene epoxidase, a key enzyme in the fungal ergosterol biosynthesis pathway. This inhibition leads to a deficiency of ergosterol, an essential component of the fungal cell membrane, ultimately resulting in increased cell membrane permeability and cell death.

The most common formulations of butenafine are creams and solutions. It is typically applied once daily for two to four weeks, depending on the type and severity of the infection. Common indications for butenafine include tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor. It is generally well-tolerated with a low incidence of local side effects such as mild burning, itching, or dryness at the application site. Systemic absorption is minimal, making it a safe option for topical use. Butenafine is available over-the-counter in many regions.