Butenafine

Butenafine is a synthetic benzylamine antifungal medication. It is primarily used topically to treat fungal infections of the skin, such as athlete's foot, jock itch, and ringworm. Butenafine works by inhibiting the enzyme squalene epoxidase, which is crucial for the synthesis of ergosterol. Ergosterol is a key component of fungal cell membranes. By disrupting ergosterol production, butenafine weakens the fungal cell membrane, leading to cell death.

The medication is available in various topical formulations, including creams and solutions. It is typically applied to the affected area once or twice daily for a prescribed duration, often several weeks. Butenafine is generally well-tolerated, with common side effects being mild and localized, such as itching, burning, or redness at the application site. Systemic absorption is minimal when used topically. It is important to complete the full course of treatment as prescribed by a healthcare professional, even if symptoms improve before the medication is finished, to ensure the infection is fully eradicated and to prevent recurrence. Butenafine is not effective against yeast infections or nail fungus.