angiotensinkonvertáló

Angiotensinkonvertáló refers to the enzyme angiotensin-converting enzyme, commonly abbreviated as ACE. This enzyme plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), a hormonal cascade that regulates blood pressure and fluid balance in the body. ACE's primary function is to convert angiotensin I, a relatively inactive peptide, into angiotensin II, a potent vasoconstrictor.

Angiotensin II, once formed, exerts its effects through several mechanisms. It directly narrows blood vessels, increasing peripheral resistance and thus blood pressure. Additionally, it stimulates the adrenal glands to release aldosterone, a hormone that promotes sodium and water reabsorption by the kidneys, further contributing to increased blood volume and pressure. Angiotensin II also influences thirst mechanisms and the release of antidiuretic hormone, both of which help conserve water.

The activity of ACE is a target for pharmacological intervention. Medications known as ACE inhibitors are widely used to treat hypertension, heart failure, and certain kidney diseases. By blocking the action of ACE, these drugs prevent the formation of angiotensin II, leading to vasodilation and reduced blood pressure. Understanding the function of angiotensinkonvertáló is therefore essential for comprehending cardiovascular physiology and the mechanisms of action of important therapeutic agents.