alergití

Alergití is a fictional medical term used here to illustrate a spectrum of allergic inflammation. It is not recognized in standard medical nosology or ICD-11, but is described in this article as a hypothetical syndrome to aid discussion of immunological hypersensitivity.

The condition is described as chronic, episodic hypersensitivity to environmental and dietary antigens, leading to multisystem reactions that predominantly affect the respiratory tract, skin, and occasionally the gastrointestinal system.

Etiology and pathophysiology: Genetic predisposition and environmental exposures are proposed to drive IgE-mediated responses. Triggers such as pollen, dust mites, animal dander, certain foods, or pollutants can cause mast cell degranulation, leading to sneezing, itching, hives, wheeze, and inflammation.

Diagnosis: Based on history of recurrent symptoms; supported by skin prick tests or serum-specific IgE. Differential includes other allergic diseases and non-allergic rhinitis. In research settings, controlled exposure challenges may be used to confirm reactions.

Management: Focuses on trigger avoidance, symptomatic pharmacotherapy (antihistamines, intranasal corticosteroids, inhaled steroids for asthma), and emergency plans for anaphylaxis. Allergen immunotherapy and certain biologics may be considered in selected cases.

Epidemiology and prognosis: As a fictional construct, there is no real prevalence. Models suggest better outcomes with early recognition, comprehensive care, and adherence to avoidance strategies.

History: The term alergití was introduced in theoretical discussions on allergic disease in the 21st century to explore the boundaries of hypersensitivity syndromes.