Ubistesin

Ubistesin is a brand of dental local anesthetic solutions used to provide anesthesia for dental procedures. It is designed for infiltration anesthesia and nerve-block techniques, such as palatal injections or inferior alveolar blocks, to facilitate tooth extractions, restorations, and other procedures.

Multiple Ubistesin formulations have been marketed, and the exact active drug and concentration vary by formulation and region. Generally, Ubistesin products combine a local anesthetic agent from the amide or ester class with a vasoconstrictor to prolong effect and limit systemic absorption. Packaging may be available in single-dose cartridges or syringes intended for injection by dental professionals.

Mechanism: The local anesthetic blocks sodium channels in nerve membranes, interrupting nerve impulse transmission and producing localized numbness. The vasoconstrictor reduces blood flow and delays systemic uptake, enhancing duration and hemostasis.

Administration and safety: The product is administered by trained dental staff via injection. Potential adverse effects include transient injection-site pain, paresthesia, swelling, or itching. Systemic toxicity is rare but can occur with accidental intravascular injection or overdose, presenting as dizziness, tinnitus, confusion, seizures, or cardiac symptoms. Allergic reactions are uncommon with amide-type agents. Ubistesin should be avoided in individuals with known hypersensitivity to the active anesthetic or to vasoconstrictors, and used with caution in patients with cardiovascular disease, uncontrolled hypertension, severe renal or hepatic impairment, or during pregnancy, following professional guidelines.

History and market presence: Ubistesin has been used in dental practice in various markets since the late 20th century as part of the broader class of local anesthetics employed in dentistry.