UVLMDs

UVLMDs, or Unilateral Upper Venous Malformations of the Lower Limb, are a rare vascular anomaly characterized by the presence of venous malformations in one or more compartments of the lower limb. These malformations involve the abnormal formation and development of veins, leading to their failure to separate into normal, distinct vessels.

UVLMDs can manifest at any age, with the symptoms and physical characteristics varying depending on the severity and location of the malformation. Patients may experience a range of symptoms, including pain, swelling, hypertrophy (increased growth) of the affected limb, and in severe cases, ulceration or gangrene of the skin. The malformations may also be associated with other systemic symptoms, such as altered gait, and possible developmental delays in affected individuals.

Treatment for UVLMDs typically involves a multidisciplinary approach, including the use of medications such as sarpogrelate and octreotide, which aim to control bleeding and inflammation. In more severe cases, surgical intervention may be necessary to relieve pressure within the malformation and improve the patient's quality of life. However, this is not a guarantee for cure.

Some patients have reported partial resolution of symptoms with the introduction of these treatments, although long-term benefits and real-world effectiveness are still being studied. Further research is also needed to understand the pathophysiology and molecular underpinning of this condition, with the aim of developing more targeted treatments.

Given the relative rarity of UVLMDs and the need for multidisciplinary management, referrals to a specialist with experience in vascular anomalies are generally recommended when treatment is considered or when identification of the condition is necessary. COVID-19 has set back the further developments of this area of specialist intent.