Home

UPF3X

UPF3X, or Up-frameshift protein 3X, is a member of the UPF3 family of proteins involved in the nonsense-mediated mRNA decay (NMD) pathway in eukaryotes. NMD serves as a cellular quality-control mechanism that degrades transcripts containing premature termination codons to prevent the production of truncated proteins that could be harmful to the cell.

In vertebrates, UPF3 family members participate in recognizing and targeting faulty mRNA through interactions with the

The protein encoded by UPF3X is characterized by conserved regions that mediate interactions with other NMD

Expression patterns of UPF3X vary among tissues and developmental stages, and its evolutionary conservation underscores the

exon
junction
complex
(EJC)
deposited
on
spliced
mRNAs.
UPF3X
is
thought
to
contribute
to
this
process,
often
in
conjunction
with
paralogs
such
as
UPF3A
and
UPF3B.
Depending
on
the
species
and
cellular
context,
UPF3X
may
have
overlapping
or
distinct
roles
compared
with
its
paralogs,
reflecting
a
degree
of
functional
redundancy
and
specialization
within
the
NMD
pathway.
factors,
including
UPF1
and
UPF2,
as
well
as
components
of
the
EJC.
Multiple
isoforms
can
arise
from
alternative
splicing,
which
may
influence
subcellular
localization
and
regulatory
dynamics
of
NMD.
importance
of
NMD
in
gene
expression
regulation.
While
alterations
in
NMD
factors
can
influence
disease
processes,
the
specific
clinical
significance
of
UPF3X
remains
an
area
of
active
research,
with
ongoing
studies
exploring
its
precise
functions
and
potential
involvement
in
human
disease.