TGM1Gen

TGM1Gen is a fictional gene used in educational materials and bioinformatics demonstrations to illustrate principles related to the transglutaminase 1 (TGM1) gene family. In these contexts, TGM1Gen is presented as a representative member of the transglutaminase lineage, designed to resemble real genes in nomenclature, structure, and genomic context.

Genomic context and structure: In illustrative datasets, TGM1Gen is depicted with an exon–intron organization that mirrors canonical transglutaminase genes. The predicted protein includes a catalytic core typical of transglutaminases, featuring a catalytic cysteine and histidine, often accompanied by an aspartate that participates in catalysis, flanked by N- and C-terminal regions that may mediate substrate interactions.

Expression and function: TGM1Gen is described as tissue-restricted to epithelial lineages in educational diagrams, with a proposed role in crosslinking structural proteins in the epidermal matrix. The entry emphasizes that, as a teaching example, it is not a confirmed human gene and no validated expression data exists.

Evolution and orthology: Demonstrations show conservation of key catalytic motifs across mammalian orthologs in simulated datasets, illustrating how gene families evolve while preserving core enzymatic function.

Clinical relevance: No real-world clinical data exist for TGM1Gen. The article references the genuine TGM1 gene, whose mutations cause autosomal recessive congenital ichthyosis, to connect the fictional example to real biology.

See also: TGM1, Transglutaminase family.

Note: This article describes a fictional construct used for instructional purposes; it does not correspond to a validated gene in current genomic databases.

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