TAK1binding
TAK1binding refers to the interactions that regulate the activity of TAK1, a serine/threonine kinase in the MAP kinase kinase kinase (MAP3K) family. TAK1 signaling integrates inflammatory and stress signals to control downstream pathways such as NF-κB and the JNK/p38 cascades.
The core binding partners of TAK1 are the TAK1-binding proteins TAB1, TAB2, and TAB3. TAB1 binds directly
Activation of TAK1 is tightly coordinated by ubiquitination. E3 ligases such as TRAF6 and the linear ubiquitin
Once activated, TAK1 phosphorylates downstream kinases, leading to activation of the IKK complex and the NF-κB